BAM 15
CAS No. 210302-17-3
BAM 15 ( —— )
Catalog No. M22567 CAS No. 210302-17-3
BAM 15 is an uncoupler of mitochondrial protonophore. BAM 15 is fully capable of increasing mitochondrial respiration in the presence of oligomycin and does so across a broader concentration range than FCCP in both myoblasts and hepatocytes and it is able to increase O2 consumption across a broad dosing range without increasing ROS.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 53 | In Stock |
|
10MG | 98 | In Stock |
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25MG | 177 | In Stock |
|
50MG | 295 | In Stock |
|
100MG | 447 | In Stock |
|
500MG | 972 | In Stock |
|
1G | Get Quote | In Stock |
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Biological Information
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Product NameBAM 15
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NoteResearch use only, not for human use.
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Brief DescriptionBAM 15 is an uncoupler of mitochondrial protonophore. BAM 15 is fully capable of increasing mitochondrial respiration in the presence of oligomycin and does so across a broader concentration range than FCCP in both myoblasts and hepatocytes and it is able to increase O2 consumption across a broad dosing range without increasing ROS.
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DescriptionBAM 15 is an uncoupler of mitochondrial protonophore. BAM 15 is fully capable of increasing mitochondrial respiration in the presence of oligomycin and does so across a broader concentration range than FCCP in both myoblasts and hepatocytes and it is able to increase O2 consumption across a broad dosing range without increasing ROS. BAM 15 and FCCP are structurally unrelated. Which is observed that low doses of BAM 15 from 100 nM to 1 μM increase cellular O2 consumption rate (OCR) to a similar degree as FCCP, However higher concentrations from 1 μM to 50 μM reveal that BAM 15 is able to maintain uncoupled respiration at a high rate in a range of cell lines. BAM 15 induces mitochondrial swelling, demonstrating that BAM 15 is a protonophore. BAM15-treated cells are more viable than FCCP-treated cells when administered across a broad dosing range up to 50 μM.Compare to vehicle-treated mice, animals that receive BAM 15 are protected from kidney injury as indicated by lower plasma creatinine levels at 24 and 48 h post-ischemia, reduced tubular necrosis, less obstruction of proximal tubules, less depletion of brush border villi, and less immune cell infiltration.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptoroxidative phosphorylation (OXPHOS)
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Research Area——
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Indication——
Chemical Information
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CAS Number210302-17-3
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Formula Weight340.29
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Molecular FormulaC16H10F2N6O
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Purity>98% (HPLC)
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SolubilityDMSO:72 mg/mL (211.58mM; Need ultrasonic)
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SMILESFc1ccccc1Nc1nc2nonc2nc1Nc1ccccc1F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Kenwood BM, et al. Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane. Mol Metab. 2013 Nov 28;3(2):114-23.
molnova catalog
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